Houston is enormous, and where you stay changes the whole trip. Cypress and the area inside Loop 610 are two very different experiences. The right choice depends on why you're here.

Cypress sits northwest of the city, about 30 minutes from downtown without traffic. It's quiet and residential, built around space. Bigger yards, more parking, fewer people on the sidewalk. If you're staying with family, bringing a car, or just want quiet at the end of the day, Cypress delivers that.
Inside the loop is the opposite trade. Neighborhoods like Montrose and the Medical Center area put you within walking distance of restaurants and transit. The tradeoff is space. Units tend to be smaller, streets are busier, and parking is rarely as simple as pulling into a driveway.

Commute time is often the real deciding factor. It depends on where you're headed each day. Cypress to downtown runs 30 to 45 minutes each way outside rush hour, longer during it. If your stay centers on the Medical Center or downtown, that daily drive adds up fast over a few weeks. If you're working in northwest Houston instead, or splitting time between both, Cypress can actually be the shorter commute.
Groceries and errands look different too. Cypress has the big-box stores and chain groceries most people expect, all within a short drive. Inside the loop, you're more likely to walk to a smaller grocery store, especially in denser pockets like Montrose.

Noise is worth thinking about too, especially for a longer stay. Cypress streets are quiet after dark, with little foot traffic and few late-night sounds. Inside the loop, especially near Montrose or Midtown, you'll hear more street noise into the evening. Neither is wrong. It depends on whether you want energy nearby or distance from it.
Cost is worth knowing about directly. A furnished stay in Cypress tends to run a little lower per night than a similar unit inside the loop. Land costs less out there, and units often run larger for the same price. If budget matters more than proximity, Cypress usually wins that comparison.
Neither option is right in general. It depends on what your stay actually needs. A family in town for a few weeks, wanting space and a yard, is often better off in Cypress. Someone here for work near the Medical Center, without a car, is usually better off inside the loop, even at a slightly higher nightly rate.
If you're not sure which fits your trip, think about how much time you'll spend near your destination each day. Compare that to how much you want a quiet place to come home to at night. That usually points you to the right neighborhood — take a look at what's available in each area and go from there.